|
KMID : 0351619650060010079
|
|
Kyungpook Medical Journal
1965 Volume.6 No. 1 p.79 ~ p.84
|
|
|
Blood Pressure Change Following Acute Carbon Monoxide Poisoning in Dogs
|
|
李錫江/Lee, Suck Kang
李文杰/金圭秀/呂雄淵/Lee, Moon Kul/Kim Kyu Soo/Ryo, Ung Yun
|
|
|
Abstract
|
|
|
The effect of acute carbon monoxide (CO) poisoning on arterial and venous blood pressure was studied in this report.
The changes in mean pressure in abdominal aorta and inferior vena cava were measured for 15 minutes in CO breathing dogs (2.5% CO, 21%O₂ in N₂), in low_ oxygen breathing dogs(10% O₂ in 16 liters of N₂) ana in total adrenalectomized and CO breathing dogs.
Experiments were so designed that blood O₂content decreased approximately the same extent and same rate in both CO breathing and low O₂rebreathing group. The results showed no significant difference in blood O₂ content in the both group.
The mean arterial pressure began to decrease following after two minutes of CO breathing and declined continuously and rather precipitously as time progressed, while in the low O₂ rebreathing dogs the arterial pressure was maintained or rather elevated for about 10 minutes and thereafter declined.
Venous pressure was elevated continuously as time progressed in both CO breathing and low O₂ rebreathing group and the elevation was more marked in CO breathing group. Such difference in blood pressure changes between the two groups was attributed to the difference in decreased cardiac out-put caused by anoxic myocardial damage. More severe myocardial damage in CO poisoning group would be possible by the fact that left side shift of oxygen dissociation curve of blood and/or inhibitory effect of CO on the cytochrome oxydase in tissues.
In adrenalectomized and CO breathing group the mean arterial pressure was maintained for about 10 minutes at significantly lower level as compared with the adrenal gland intact and CO breathing group and declined thereafter gradually. The causes of maintained arterial pressure in the adrenalectomized group, even though at lower level, are not certain. But it is plausible as the effect of adrenalin for maintenance of blood pressure is said to be abolished under severe anoxic state.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|